"Computational, Biological, and Clinical Approach to Mechanistic Understanding of Cerebral Aneurysms and Their Treatment" w. Juan Cebral, Professor of Bioengineering, George Mason University
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🧬 UVA Biomedical Engineering Seminar Series
Featured Speaker: Juan Cebral, Ph.D.
Professor of Bioengineering
George Mason University
📅 Event Details
- Date: Friday, November 14, 2025
- Location: BME Lecture Hall, MR5 1041
- Time: 1:45 PM – 3:30 PM
- 1:45 PM – Refreshments
- 2:00 PM – Presentation
- 3:00 PM – Meet the Speaker
🧠 SEMINAR: "Computational, Biological, and Clinical Approach to Mechanistic Understanding of Cerebral Aneurysms and Their Treatment"
Brain aneurysms are pathological focal dilatations of the cerebral arteries which affect a significant portion of the general population (2-5%). Rupture of a cerebral aneurysm has devastating consequences with high mortality and morbidity. However, rupture of incidentally found asymptomatic aneurysms is quite rare. Nevertheless, preventive treatment is often recommended even though the risk of treatment complications may exceed the natural rupture risk. As such, precise assessment of aneurysm risk is very important to guide patient management. Current aneurysm evaluation relies mostly on patient characteristics (demographics, age, smoking, hypertension, family history, etc.) and very few aneurysm-specific characteristics (only size, location and presence of blebs). Thus, one of the goals of our research is to improve aneurysm evaluation and management through detailed understanding of the underlying mechanisms that drive the degradation of the aneurysm wall and its subsequent weakening and ultimately failure. The second goal of our research is to optimize minimally invasive procedures and devices to improve outcomes and minimize complications, again by detailed understanding of the healing process after treatment.
👨🔬 About the Speaker
Dr. Juan R. Cebral is a Professor with the Departments of Bioengineering and Mechanical Engineering of the College of Engineering and Computing at George Mason University. He finished his undergraduate studies in Physics at the University of Buenos Aires, Argentina in 1991 and received his PhD in Computational Sciences and Informatics from George Mason University in 1996. Dr. Cebral conducts research on image-based patient-specific computational fluid dynamics modeling of cerebral blood flow and aneurysms in close collaboration with clinicians and medical researchers from several institutions. He is also a member of the Center for Computational Fluid Dynamics of the College of Sciences at GMU. He has co-authored over 150 journal papers, 10 book chapters, and over 215 conference papers. His current h-index is 66. His research has been funded by the National Institutes of Health, the American Heart Association, the Whitaker Foundation as well as industrial partners such as Philips Healthcare and Boston Scientific. He teaches courses in Fluid Mechanics, Biomechanics and Transport, and Multi-Scale Modeling in Biomedicine.